Manchester United endured a frustrating afternoon in the Premier League on Sunday with a 0-0 draw against bottom-placed Southampton marked by midfielder Casemiro being sent off.
Casemiro's 34th-minute dismissal for a dangerous high boot against Carlos Alcaraz gave confidence to the visitors and made for an entertaining game with great chances at both ends.
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United captain Bruno Fernandes came closest for the hosts in the second half with a low shot off the post while prolific striker Marcus Rashford saw a shot well saved in a one-on-one with Southampton goalkeeper Gavin Bazunu in the first period.
Southampton missed a string of chances, with Theo Walcott seeing a point-blank header and curling shot both brilliantly saved by David De Gea, while Kyle Walker-Peters hit the post and James Ward-Prowse saw a couple of free kicks go close.
The result was not what United manager Erik ten Hag wanted after last week's 7-0 drubbing by Liverpool in the league and was a disappointing follow-up to the scintillating 4-1 Europa League win over Real Betis in midweek.
A point each left Manchester United third in the league on 50 points, 16 behind leaders Arsenal, while Southampton stayed bottom on 22, two points off safety in a packed fight against relegation to the Championship.
The home fans at Old Trafford were incensed by a series of penalty appeals that referee Anthony Taylor dismissed.
Adding to their ire, the referee had originally given Casemiro a yellow card before changing it to red after a video check.