Forwards - Jadon Sancho, Wout Weghorst, Facundo Pellistri
With Alejandro Garnacho definitely out and Anthony Elanga lacking form, Ten Hag could field a strong attack with Jadon Sancho brought back into the starting lineup to replace Antony. The Brazilian was absent from Wednesday's training session to pile on Ten Hag's injury worries and had been ruled out due to illness.
Garnacho will miss the game after coming off injured against Southampton following a challenge from Saints' right-back Kyle Walker-Peters. The 18-year-old's injury was discovered after linking up with the Argentina squad and he will be out until after the international break.
Anthony Martial has been training with the rest of the group but Ten Hag is being cautious about a return, with the Frenchman currently managing the hip problem that has kept him out since the beginning of February. That means Weghorst could maintain his run of starting every game since joining on loan from Burnley.
And if Rashford is handed a rest, Facundo Pellistri could be given a start after his impressive performances from the bench.
Free £2 shop bet with William Hill every day of the Cheltenham Festival - plus all the fantastic daily coverage you need
Pick up your Daily Express every day of the festival for racing specials, day by day updates and free bet EVERY DAY.
Celebrate the biggest racing week of the year- the Cheltenham Festival. One of the most prestigious National Hunt Meetings of the calendar is not to be missed…and we’ve got a bumper week of amazing content and great reader offers. Find out more HERE