Manchester United face Sevilla in the Europa League quarter-finals, three years after their last meeting in 2020.
United have never beaten Sevilla, being knocked out in both ties when drawn against them.
In 2020, Ole Gunnar Solskjaer led the Red Devils to the Europa League semi-finals in the behind-closed-doors one-legged tournament amid the impact of Covid.
And after Fernandes fired United ahead, a collapse saw Suso and Luuk de Jong complete the turnaround and set up a final against Inter Milan.
Fernandes couldn't contain his fury after the Red Devils fell behind, unleashing on Victor Lindelof, clearly blaming him for the second goal.
It was a lowly night and the latest cup run that blew up at one of the final hurdles under Solskjaer.
United will hope Erik ten Hag can break the Sevilla curse, starting with a win on Thursday.